Men's HealthAsad K. Niazi, MD, MPH
Board Certification
Internal Medicine (ABIM)
Alma Mater
Texas Tech University – Foster School of Medicine
Sexual Health
As needed injection
Trimix Injections
Maximum strength injectable for reliable results
Starting at $160$200
30-day SupplyTreatment plan includes no-cost medical evaluation with a men's health expert
Check Eligibility →Free provider review • You pay $0 if not approved
Formulation
One 5mL vial contains up to 10 injections at maximum dose (0.50mL)
Trimix T-105Papaverine 30mg / Phentolamine Mesylate 1mg / Prostaglandin E1 10mcg
Pricing applicable to the first shipment of a 30-day supply of medication. Second and subsequent refills are $200. Introductory discount of $40 ends 10/31/2026 at 11:59pm.
Prescription Required
Doctor Prescribed
100% Online
UPS Next Day Air
No Waiting Rooms
No Membership Fees
FSA/HSA Eligible
When pills have stopped working, this is what works.
Choose Your Supply
Larger supplies unlock the best per-dose pricing.
Every RWell Plan Includes:
- Free Provider Consultation
- Medication & supplies
- UPS Next Day Air
- Ongoing medical support
LegitScript CertifiedSTANDARD OPTION
10 DOSES PER VIAL
10 DOSES PER VIAL
30 Day Supply (5mL)
$160first order
Second and subsequent refills $200/per 30-day supply of medication
CHECK ELIGIBILITY
Auto Refills – Cancel Anytime
Most Popular
BEST VALUE
90 Day Supply (15mL)
$499total
SAVE $101
Includes 3x 5mL vials
CHECK ELIGIBILITY
Auto Refills – Cancel Anytime
How it works
Start
Start from your phone
Answer a few questions about your health and goals.
⏱ 5-10 minutes
Review
A clinician reviews your requested treatment
They decide whether treatment is appropriate. No video visit required in 41 states.
⏱ <4 business hours
Delivered
Your treatment ships
One of our trusted pharmacy partners discreetly ships your medication to your doorstep.
⏱ <1 week*
*Timelines shown reflect our average turnaround times and are not guaranteed.
Results you'll feel with TriMix
Direct, fast-acting support built around your response.
Up to ~90% of men achieved erections suitable for intercourse in clinical studies.6
Works when pills don't
Fast onset, lasting 30–90 minutes. No waiting on absorption or an empty stomach.
Ready in minutes
Acts directly on erectile tissue, so it works even when your head's not in it.
Stress can't shut it down
Your provider sets the protocol. You fine-tune it to what works.
Dosed to you
Formulation and dosing
- Formulation
- Trimix T-105: Papaverine 30mg / Phentolamine Mesylate 1mg / Prostaglandin E1 10mcg
- Doses per vial
- Each 5 mL vial contains up to 10 doses at the maximum prescribed dose of 0.50 mL.
- Onset and duration
- Typically begins working within 5–20 minutes after injection, and the effect generally lasts 30–90 minutes.
- Compounded by
- Olympia Pharmaceuticals Dispensing Pharmacies: ThePharmacyHub
- Included
- Injection kit (syringes, needles, alcohol wipes) • Expedited shipping • Ongoing provider messaging
- Risks
- Prolonged erection and priapism can occur in patients receiving penile injection therapy. To minimize the chances of this occurring, titrate TriMix slowly to the lowest effective dose, and never combine with oral ED meds or supplements. Seek immediate medical attention for an erection that persists longer than 4 hours.
- Standard dosing protocol
- Your prescriber may adjust this: Inject 0.05 mL (5 units) at the base of the penis before sexual activity. Increase by 0.025–0.05 mL (2.5-5 units) based on response. Wait at least 24 hours before repeating or increasing the dose. Maximum 0.50 mL (50 units) per dose; no more than 3 doses per week.
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Your care team
Meet the doctors
Men's Health
LongevityShannon Arora, MD
Board Certification
Family Medicine (ABFM)
Alma Mater
Xavier University School of Medicine
LongevitySean Arora, MD
Board Certification
Family Medicine (ABFM)
Alma Mater
Xavier University School of Medicine
Men's HealthAbhishek Patel, DO
Board Certification
Physical Medicine and Rehabilitation (ABPMR)
Alma Mater
Lake Erie College of Osteopathic Medicine
Oversight
Physician reviewed
Dose
Three powerful compounds work together for maximum effectiveness.
Frequency
As needed injection
Included
Medication, supplies, expedited shipping
Frequently Asked Questions
Who is Trimix for?
Trimix is ideal for men who haven't had success with oral ED medications or need a more reliable solution. It's particularly effective for those with diabetes, prostate surgery history, or other conditions affecting blood flow.
How effective is Trimix?
TriMix is widely considered the most effective ED treatment available, with reported success rates over 90% — including for men who didn’t respond to oral medications like sildenafil or tadalafil. Because it’s injected directly into the penis, it works independently of arousal and nerve signaling, which is why results are so consistent.
That said, individual results vary. Response depends on the underlying cause of your ED, your overall health, and finding the right dose — which is why your prescription includes a titration protocol to dial in what works for you. Most men find their effective dose within the first few injections.
Just like any local brick and mortar pharmacy, we can’t accept returns or issue refunds on dispensed medication. TriMix is compounded specifically for you, and we don’t guarantee a specific treatment outcome, but our prescribers will work with you on dosing adjustments to get the best possible result.
That said, individual results vary. Response depends on the underlying cause of your ED, your overall health, and finding the right dose — which is why your prescription includes a titration protocol to dial in what works for you. Most men find their effective dose within the first few injections.
Just like any local brick and mortar pharmacy, we can’t accept returns or issue refunds on dispensed medication. TriMix is compounded specifically for you, and we don’t guarantee a specific treatment outcome, but our prescribers will work with you on dosing adjustments to get the best possible result.
What's in TriMix? What is the dosing?
RespondWell uses the T-105 formulation: • Papaverine 30mg • Phentolamine Mesylate 1mg • Prostaglandin E1 10mcg. Compounded by Hallandale or Olympia Pharmacy. A 1-month supply is 5 mL; a 3-month supply is 15 mL (three 5 mL vials). Some patients may alternatively be prescribed Papaverine 30mg • Phentolamine Mesylate 2mg • Prostaglandin E1 40mcg.
Standard dosing protocol — your prescriber may adjust this: Inject 0.05–0.10 mL at the base of the penis before sexual activity. Increase by 0.025–0.05 mL based on response. Wait at least 48 hours before repeating or increasing the dose. Maximum 0.50 mL per dose; no more than 3 doses per week.
→ Instructions: Penile Injection Instructions (PDF) →
Standard dosing protocol — your prescriber may adjust this: Inject 0.05–0.10 mL at the base of the penis before sexual activity. Increase by 0.025–0.05 mL based on response. Wait at least 48 hours before repeating or increasing the dose. Maximum 0.50 mL per dose; no more than 3 doses per week.
→ Instructions: Penile Injection Instructions (PDF) →
How long does a vial last?
One 5mL vial holds up to 10 injections at the maximum dose (0.50mL). Dosed every 3 days — the most frequent schedule your provider will approve — that works out to right around 30 days.
Here's the part that actually matters: the vial has a four week life after the first puncture, and that clock is what governs, not how much is left. Even if you're dosing below 0.50mL and have solution to spare, discard the vial after four weeks. The potency and sterility of your vial cannot be assured after that point, regardless of the remaining volume. A half-full vial on day 30 isn't a bonus — it's a vial you shouldn't be drawing from.
Bottom line: Order your refill with enough lead time that you're not stretching a vial past its date to bridge a gap.
Here's the part that actually matters: the vial has a four week life after the first puncture, and that clock is what governs, not how much is left. Even if you're dosing below 0.50mL and have solution to spare, discard the vial after four weeks. The potency and sterility of your vial cannot be assured after that point, regardless of the remaining volume. A half-full vial on day 30 isn't a bonus — it's a vial you shouldn't be drawing from.
Bottom line: Order your refill with enough lead time that you're not stretching a vial past its date to bridge a gap.
Do I have to commit to auto refill?
No. Every plan is fully flexible — pause, delay, reschedule, or cancel whenever you want, right from your patient portal or with a quick message to our team. Your next refill date is always shown on your portal and in every confirmation email, and you'll get an email and text before anything processes, so there are never surprises. Refills run every 25 days on monthly plans and every 85 days on quarterly, timed so your next supply arrives before you run out. The only ask: make changes at least 48 hours before the refill date shown so we can pull the order before the pharmacy fills it. Full flexibility, full transparency — you're always in control.
One note for injectables like TriMix: per FDA/USP guidelines, vials have a 28-day beyond-use date once punctured. Our plans have been priced to ensure you never have to choose between safety and affordability.
One note for injectables like TriMix: per FDA/USP guidelines, vials have a 28-day beyond-use date once punctured. Our plans have been priced to ensure you never have to choose between safety and affordability.
Do you offer other formulations like Super TriMix, BiMix, QuadMix, or T-106?
Our standard formulation is T-105 TriMix (papaverine 30 mg / phentolamine 1 mg / PGE1 10 mcg per mL), and it’s the only one we prescribe for new patients. T-105 is a well-established, balanced formula that works for the vast majority of men, and standardizing on it lets our prescribers fine-tune your results through dosing adjustments rather than switching formulas. It also means our pharmacy compounds it at higher volume, which keeps quality consistent and pricing lower.
Super TriMix (papaverine 30 mg / phentolamine 2 mg / PGE1 40 mcg per mL) is available on special request only. It contains four times the alprostadil (PGE1) and twice the phentolamine of T-105, and it’s priced at $249 per 5 mL vial. It is not an option for first-time patients — your prescriber will only consider it after you’ve titrated through T-105 per protocol without an adequate response. Super TriMix is also not available for shipment to Alabama, Arkansas, California, Hawaii, Kansas, Michigan, Minnesota, or Mississippi.
We do not offer BiMix, QuadMix, or T-106.
Super TriMix (papaverine 30 mg / phentolamine 2 mg / PGE1 40 mcg per mL) is available on special request only. It contains four times the alprostadil (PGE1) and twice the phentolamine of T-105, and it’s priced at $249 per 5 mL vial. It is not an option for first-time patients — your prescriber will only consider it after you’ve titrated through T-105 per protocol without an adequate response. Super TriMix is also not available for shipment to Alabama, Arkansas, California, Hawaii, Kansas, Michigan, Minnesota, or Mississippi.
We do not offer BiMix, QuadMix, or T-106.
How fast can I get TriMix?
Fast. Our goal is to have your medication at your door by this time next week, at the latest—and we meet that goal about 94% of the time.
Here's what that usually looks like:
Provider review: Most intakes are reviewed within 4 business hours. More complex medical histories may require additional review by our Medical Director or care team.
Pharmacy processing: Once approved, our partner pharmacy typically prepares and ships your medication within 1–3 business days.
Shipping: UPS Next Day Air is included at no additional cost.
Keep in mind that pharmacy volume, holidays, severe weather, and other carrier delays can occasionally extend these timelines. We'll keep you updated every step of the way.
Here's what that usually looks like:
Provider review: Most intakes are reviewed within 4 business hours. More complex medical histories may require additional review by our Medical Director or care team.
Pharmacy processing: Once approved, our partner pharmacy typically prepares and ships your medication within 1–3 business days.
Shipping: UPS Next Day Air is included at no additional cost.
Keep in mind that pharmacy volume, holidays, severe weather, and other carrier delays can occasionally extend these timelines. We'll keep you updated every step of the way.
What are the side effects of Trimix?
Common side effects include mild pain at the injection site, prolonged erection, and minor bruising. The most serious risk is priapism (erection lasting more than 4 hours), which requires immediate medical attention. Proper dosing and technique may reduce these risks.
Penile Injection Instructions (PDF) →
Penile Injection Instructions (PDF) →
Do you prescribe phenylephrine injections for prolonged erections or priapism?
Yes, Phenylephrine is available as an add-on at checkout. You may also purchase it at a later date from within your patient portal, though it's considerably cheaper to purchase at the same time (as we can ship it in the same box, and approve it under one clinical encounter).
Is TriMix available in California?
Yes. TriMix is available to eligible patients in California following a review by a licensed clinician. If you're approved for treatment, your prescription will be sent to one of our partner pharmacies for fulfillment and discreet delivery.
Which states is TriMix available in?
TriMix is available to eligible patients in all 50 states and Washington, D.C.
Every prescription is reviewed by a licensed clinician in your state. If treatment is appropriate, your medication is prepared by one of our partner pharmacies and shipped directly to your door in discreet packaging.
Every prescription is reviewed by a licensed clinician in your state. If treatment is appropriate, your medication is prepared by one of our partner pharmacies and shipped directly to your door in discreet packaging.
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Related Reading
More on Trimix Injections
Deeper dives from our editorial team — pricing, dosing, and the research behind it.
Ready to Get Started?
Check Eligibility for Trimix Injections*Trimix is a compounded injectable medication (alprostadil, papaverine, and phentolamine) and is not FDA-approved. Compounded medications have not undergone FDA premarket review for safety, effectiveness, or quality. The suggested formulations are provided for reference only and are based on formulations that have historically been prescribed by duly licensed prescribers. All medications are prepared in accordance with a valid prescription from a licensed healthcare provider following a medical consultation. Seek immediate medical attention for an erection lasting more than 4 hours (priapism).